Insulin as a regulator of flavin-containing monooxygenase enzyme in streptozotocin-induced diabetic rats Ph.D. Thesis

ABBREVIATIONS AA amino acid ANOVA one-way analysis of variance Asn 120 asparagine 120 BG blood glucose concentration BOR benzamidoxime reductase BZY benzydamine BZY N-oxide benzydamine N-oxide cDNA complementary DNA CYP cytochrome P450 cyt.b 5 cytochrome b 5 D50 50 mg/kg streptozotocin induced diabetic rats D70 70 mg/kg streptozotocin induced diabetic rats DAG diacyl-glycerol DIM 3,3'diindolylmethane DTT dithiotreitol EDTA ethylenediamine-tetraacetic acid FAD flavin adenine dinucleotide FADH 2 reduced flavin adenine dinucleotide FADOH hydroxy flavin dinucleotide FADOOH hydroperoxy flavin dinucleotide FMO flavin-containing monooxygenase GAPDH glyceraldehyde-3-phosphate dehydrogenase GDT guanylyl diphosphate GSH reduced glutathione GSSG oxidized glutathione GLUT-2 glucose transporter 2 Grb2 an adaptor protein containing SH2 GTP guanylyl triphosphate HLM human liver microsomes HNF1α hepatic nuclear factor, homeodomain-containing factor HNF4α hepatic nuclear factor, orphan nuclear receptor I3C indole-3-carbinol ID70 insulin treated 70 mg/kg streptozotocin induced diabetic rats IDDM insulin-dependent diabetes mellitus IGF-1 insulin-like growth factor IND insulin treated non-diabetic rats IP 3 inozitol 1,4,5-triphosphate IRS insulin receptor substrate LT 2,3-bis[3-indolylmethyl]indole, (linear tetramer) MAO-B monoamine oxidase type B MAP kinase mitogen activated protein kinase MMI methimazole MPDP + 2,3-dihydropyridinium MPP + 1-methyl-4-phenylpyridinium MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP N-oxide 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide 4 MpTS methyl para-tolyl sulfide MpTSO methyl para-tolyl sulfoxide mRNA messenger ribonucleic acid NADPH reduced nicotinamide adenine dinucleotide phosphate NADP + nicotinamide adenine dinucleotide phosphate NIDDM noninsulin dependent diabetes mellitus PDB ID protein data bank identification PCR polymerase chain reaction PIP2 phosphatidyl-inositol 4,5 biphosphate PKC proteinkinase C PLC-γ phospholipase C-γ PTP 4-phenyl-1,2,3,6-tetrahydropyridine ras guanine nucleotide-binding protein RIN RNA Integrity Number RNA ribonucleic acid RLM rat liver microsomes SH2 domain src homology domain 2 SNP single nucletide polymorphism SOS Ras-specific nucleotide exchange factor Src kinase a non-receptor tyrosine kinase STZ streptozotocin TCA trichloro acetic acid TMA trimethylamine TMA N-oxide trimethylamine N-oxide TMAuria trimethylaminuria Tris tris hydroxymethyl aminomethane YY1 Yin Yang-1 1get PDB ID of glutathione-reductase 1npx PDB ID of NADPH-peroxidase 1vqw PDB ID of a protein with similarity to FMO 1w4x PDB ID of phenylacetone monooxygenase 5-DPT